[99mTcN(PNP5)(NOEt)]+: A novel potential myocardial perfusion imaging agent

Document Type

Article

Publication Date

7-1-2006

Abstract

The asymmetrical [99mTcN(PNP5)(NOEt)]+ heterocomplex containing a terminal technetium-nitrogen multiple bond coordinated to the diphosphine ligand (PNP5) and the dithiocarbamate ligand (NOEt), was prepared through ligand exchange reaction. Its radiochemical purity was over 90% as measured by TLC and HPLC. Biodistribution in mice and SPECT imaging in dog were studied. The results showed that [99mTcN(PNP5)(NOEt)]+ possessed high myocardial uptake and good retention, and high target to non-target ratios, suggesting that it may be a potential myocardial perfusion imaging agent. © 2006 Akadémiai Kiadó.

Publication Source (Journal or Book title)

Journal of Radioanalytical and Nuclear Chemistry

First Page

175

Last Page

179

This document is currently not available here.

Share

COinS