Novel 99mTc-nitride heterocomplexes as potential myocardial perfusion imaging agents

Document Type

Article

Publication Date

6-1-2006

Abstract

To develop a new potential myocardial imaging agent, [99mTcN(PNP5) (DEDC)]+ and [99mTcN(PNP5) (DPODC)]+ were prepared through ligand exchange reaction. Their radiochemical purities were over 90%. The results of biodistribution in mice indicate that they possessed a high myocardial uptake, rapid clearance from non-target tissues and good ratios of target to non-target. And [99mTcN(PNP5) · (DEDC)]+ is superior. SPECT imaging in dog shows that its properties were similar to those of 99mTc-tetrofosmin. Based on its promising characters, it may be suitable for myocardial perfusion imaging.

Publication Source (Journal or Book title)

Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities

First Page

1016

Last Page

1019

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