Asymmetric Baylis-Hillman reaction in poly(ethyleneglycol)(400)
Document Type
Article
Publication Date
9-1-2006
Abstract
Chiral amino alcohol 1 was prepared from L-proline conveniently. In poly(ethyleneglycol) (PEG)(400), this chiral amino alcohol (30 mol%) catalyzes asymmetric Baylis-Hillman reaction effectively. High yields (up to 95.4%) and modest selectivities (up to 54.3% ee) were achieved. The chiral amino alcohol-PEG(400) catalytic system could be easily recovered and reused in the next run. No significant changes in the reaction yields and selectivities were found in the first three runs.
Publication Source (Journal or Book title)
Chinese Journal of Organic Chemistry
First Page
1306
Last Page
1308
Recommended Citation
Ding, Y., Ding, Y., Shen, Z., Li, B., & Zhang, Y. (2006). Asymmetric Baylis-Hillman reaction in poly(ethyleneglycol)(400). Chinese Journal of Organic Chemistry, 26 (9), 1306-1308. Retrieved from https://repository.lsu.edu/ag_exst_pubs/863