Benzocaine modified maleic anhydride cyclohexyl-1, 3-dioxepin copolymer, preparation and potential medical applications
Document Type
Conference Proceeding
Publication Date
1-1-1990
Abstract
The maleic anhydride-cyclohexyl-1, 3-dioxepin co-polymer, poly (MAn-CDA) Was chosen for in vitro cytotoxic activity of anionic products investigated in the present paper. Recently liposomes have gained acceptance as potential drug carriers. Consequently, the cytotoxic effect of anionic polymers considered in the present investigation was assessed for liposome encapsulated materials too. Benzocaine was chosen as a spacer since its detachment from the macromolecular support through hydrolysis of the amide link can be evaluated in vitro through its anesthetic effect. Encapsulation in liposomes of polycarboxylic product had a beneficial effect.
Publication Source (Journal or Book title)
American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
First Page
464
Last Page
465
Recommended Citation
Negulescu, I., Simionescu, C., Uglea, C., Hary, O., Grecianu, A., & Ottenbrite, R. (1990). Benzocaine modified maleic anhydride cyclohexyl-1, 3-dioxepin copolymer, preparation and potential medical applications. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, 31 (2), 464-465. Retrieved from https://repository.lsu.edu/textile_pubs/212