Ovariectomy fails to modify the myosin isoenzyme distribution muscle in striated muscle of 10-month old rats

Document Type

Article

Publication Date

12-1-1997

Abstract

Previous work suggests that the hormone estrogen can regulate myosin isoenzyme distribution in the hearts of young rats (Circ. Res. 61:12, 1987). It is unknown whether this regulatory influence 1) extends to skeletal muscle, and 2) occurs in older rats. To make this determination, estrogen levels were reduced in 9-10 month old retired breeders by ovariectomy (EXPER animals N=6). Nine weeks later the heart, soleus, red vastus and white vastus muscles were removed from the EXPER group and age matched, untreated control animals (CONTR, N=6). Myosin was isolated from these muscles and the native myosin isoenzymes separated by PAGE and quantified. Atrophied uteri and the absence of ovarian tissue suggest that the EXPER animals were estrogen deficient. The myosin isoenzyme profile did not differ between groups regardless of the muscle. These data suggest that the ability of estrogen to regulate myosin isoenzyme expression in striated muscle is limited to the young, developing animal.

Publication Source (Journal or Book title)

FASEB Journal

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