Document Type
Article
Publication Date
5-1-2015
Abstract
Resistant starch (RS) is a dietary fermentable fiber that decreases body fat accumulation, and stimulates the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) in rodents. GLP-1 and PYY are gut-secreted hormones with antiobesity effect. Thus, blocking the signals of increased GLP-1 and PYY may also block the effect of dietary RS on body fat. In a 10-week study, C57BL/6J and GLP-1 receptor null (GLP-1R KO) mice were fed control or 30% RS diet, and received daily intraperitoneal injection of either saline or PYY receptor antagonist (BIIE0246, 20 μg/kg body weight). Dietary RS significantly decreased body fat accumulation only in wild-type mice that has saline injection, but not in GLP-1R KO mice. PYY receptor antagonist diminished RS action on body fat in wild-type mice, but did not interfere with GLP-1R KO mice response to RS. Regardless of genotype and injection received, all RS-fed mice had increased cumulative food intake, cecal fermentation, and mRNA expression of proglucagon and PYY. Thus, our results suggest that increased GLP-1 and PYY is important in RS effects on body fat accumulation.
Publication Source (Journal or Book title)
Molecular Nutrition and Food Research
First Page
1000
Last Page
1003
Recommended Citation
Zhou, J., Martin, R., Raggio, A., Shen, L., McCutcheon, K., & Keenan, M. (2015). The importance of GLP-1 and PYY in resistant starch's effect on body fat in mice. Molecular Nutrition and Food Research, 59 (5), 1000-1003. https://doi.org/10.1002/mnfr.201400904
