Title

Selective protonation at a C-F bond in the presence of an iridium-methyl bond gives diastereoselective carbon-fluorine bond activation and carbon-carbon bond formation. A new path to carbon stereocenters bearing fluorine atoms

Document Type

Article

Publication Date

11-11-2002

Abstract

Reaction of iridium-fluoroalkyl complexes with fluoride acceptors occurred with completely diastereoselective activation of a C-F bond and formation of a new C-C bond. Protonation occurred with complete selectivity at the C-F bond without any detectable formation of methane by protonation at the Ir-CH3 group. It was also found that the protonation reaction occurred with no elimination of methane.

Publication Source (Journal or Book title)

Organometallics

First Page

4902

Last Page

4904

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