Title
Selective protonation at a C-F bond in the presence of an iridium-methyl bond gives diastereoselective carbon-fluorine bond activation and carbon-carbon bond formation. A new path to carbon stereocenters bearing fluorine atoms
Document Type
Article
Publication Date
11-11-2002
Abstract
Reaction of iridium-fluoroalkyl complexes with fluoride acceptors occurred with completely diastereoselective activation of a C-F bond and formation of a new C-C bond. Protonation occurred with complete selectivity at the C-F bond without any detectable formation of methane by protonation at the Ir-CH3 group. It was also found that the protonation reaction occurred with no elimination of methane.
Publication Source (Journal or Book title)
Organometallics
First Page
4902
Last Page
4904
Recommended Citation
Hughes, R., Zhang, D., Zakharov, L., & Rheingold, A. (2002). Selective protonation at a C-F bond in the presence of an iridium-methyl bond gives diastereoselective carbon-fluorine bond activation and carbon-carbon bond formation. A new path to carbon stereocenters bearing fluorine atoms. Organometallics, 21 (23), 4902-4904. https://doi.org/10.1021/om020718i