Document Type
Article
Publication Date
4-1-2007
Abstract
The innate immune system uses a wide variety of pattern recognition receptors including TLRs, scavenger receptors, and lectins to identify potential pathogens. A carefully regulated balance between activation and inhibition must be kept to avoid detrimental and inappropriate inflammatory responses. In this study, we identify murine-paired Ig-like receptor (PIR)-B, and its human orthologs Ig-like transcript 2 and Ig-like transcript 5 as novel receptors for Staphylococcus aureus. PIR-B contains four ITIM motifs and is thought to be an inhibitory receptor. Expression of these receptors enables NIH3T3 cells to bind S. aureus. In mouse bone marrow-derived macrophages, masking of PIR-B by anti-PIR mAb or genetic deletion of PIR-B shows significantly impaired recognition of S. aureus and enhanced TLR-mediated inflammatory responses to the bacteria. These data suggest a novel mechanism for innate immune regulation by paired Ig-Iike receptor family members. Copyright © 2007 by The American Association of Immunologists, Inc.
Publication Source (Journal or Book title)
Journal of Immunology
First Page
4250
Last Page
4259
Recommended Citation
Nakayama, M., Underhill, D., Petersen, T., Li, B., Kitamura, T., Takai, T., & Aderem, A. (2007). Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production. Journal of Immunology, 178 (7), 4250-4259. https://doi.org/10.4049/jimmunol.178.7.4250