Asymmetric syntheses of 8-oxabicyclo[3,2,1]octanes: A cationic cascade cyclization

Authors

Bin Li, University of Science and Technology of China
Yu Jun Zhao, University of Michigan, Ann Arbor
Yin Chang Lai, University of Science and Technology of China
Teck Peng Loh, University of Science and Technology of China

Document Type

Article

Publication Date

8-6-2012

Abstract

High octane: A novel and practical syntheses of 8-oxabicyclo[3.2.1]octanes using a cationic cascade cyclization reaction has been developed (see scheme; TIPS=triisopropylsilyl). The diastereomer of the cyclization product isolated depends upon whether the acetal or aldehyde substrate is used. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Publication Source (Journal or Book title)

Angewandte Chemie - International Edition

First Page

8041

Last Page

8045

Recommended Citation

Li, B., Zhao, Y., Lai, Y., & Loh, T. (2012). Asymmetric syntheses of 8-oxabicyclo[3,2,1]octanes: A cationic cascade cyclization. Angewandte Chemie - International Edition, 51 (32), 8041-8045. https://doi.org/10.1002/anie.201202699