Document Type
Article
Publication Date
11-1-2012
Abstract
A straightforward method has been developed for the synthesis of the benzimidazole ring system through a carbon-nitrogen cross-coupling reaction. In the presence of 2.0 equiv. of K 2CO 3 in water at 100 °C for 30 h, the intramolecular cyclization of N-(2-iodoaryl)benzamidine provides benzimidazole derivatives in moderate to high yields. Remarkably, the procedure occurs exclusively in water and doesn't require the use of any additional reagent/catalyst, rendering the methodology highly valuable from both environmental and economical points of view. © 2012 by the authors.
Publication Source (Journal or Book title)
Molecules
First Page
12506
Last Page
12520
Recommended Citation
Chen, C., Chen, C., Li, B., Tao, J., & Peng, J. (2012). Aqueous synthesis of 1-H-2-substituted benzimidazoles via transition-metal-free intramolecular amination of aryl iodides. Molecules, 17 (11), 12506-12520. https://doi.org/10.3390/molecules171112506