Interferon-Mediated Response to Human Metapneumovirus Infection

Authors

Ifeanyi K. Uche, Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA. iuche1@lsu.edu.
Antonieta Guerrero-Plata, Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA. aguerrp@lsu.edu.

Document Type

Article

Publication Date

9-18-2018

Abstract

Human metapneumovirus (HMPV) is one of the leading causes of respiratory diseases in infants and children worldwide. Although this pathogen infects mainly young children, elderly and immunocompromised people can be also seriously affected. To date, there is no commercial vaccine available against it. Upon HMPV infection, the host innate arm of defense produces interferons (IFNs), which are critical for limiting HMPV replication. In this review, we offer an updated landscape of the HMPV mediated-IFN response in different models as well as some of the defense tactics employed by the virus to circumvent IFN response.

Publication Source (Journal or Book title)

Viruses

Recommended Citation

Uche, I. K., & Guerrero-Plata, A. (2018). Interferon-Mediated Response to Human Metapneumovirus Infection. Viruses, 10 (9) https://doi.org/10.3390/v10090505