The Relevance of TLR8 in Viral Infections

Authors

Iván Martínez-Espinoza, Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Antonieta Guerrero-Plata, Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.

Document Type

Article

Publication Date

1-22-2022

Abstract

Toll-like receptors (TLRs) are the largest pattern recognition receptors responsible for activating the innate and adaptive immune response against viruses through the release of inflammatory cytokines and antiviral mediators. Viruses are recognized by several TLRs, including TLR8, which is known to bind ssRNA structures. However, the similarities between TLR8 and TLR7 have obscured the distinctive characteristics of TLR8 activation and its importance in the immune system. Here we discuss the activation and regulation of TLR8 by viruses and its importance in therapeutical options such as vaccine adjuvants and antiviral stimulators.

Publication Source (Journal or Book title)

Pathogens (Basel, Switzerland)

Recommended Citation

Martínez-Espinoza, I., & Guerrero-Plata, A. (2022). The Relevance of TLR8 in Viral Infections. Pathogens (Basel, Switzerland), 11 (2) https://doi.org/10.3390/pathogens11020134