The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series

Authors

Harry J. Gould, Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Samantha Edenfield, Department of Pharmacology and Experimental Therapeutics, USA.
Paige R. Miller, Oleander Medical Technologies, Baton Rouge and New Orleans, LA, USA.
Kelly Jean Sherman, Department of Pharmacology and Experimental Therapeutics, USA.
Brian Melius, Metairie Small Animal Hospital, Metairie, LA, USA.
Alissa Whitney, Monroe Street Animal Hospital, Mandeville, LA, USA.
Robert P. Hunter, One Medicine Consulting, Olathe, KS, USA.
Fabio Del Piero, Department of Pathobiological Sciences and Louisiana Animal Disease Diagnostic Laboratory (LADDL), Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, USA.
Dennis Tracey, Oleander Medical Technologies, Baton Rouge and New Orleans, LA, USA.
Dennis Paul, Oleander Medical Technologies, Baton Rouge and New Orleans, LA, USA.

Document Type

Article

Publication Date

1-1-2022

Abstract

Background: Targeted osmotic lysis (TOL) is a novel technology that involves concomitant stimulation of voltage-gated sodium channels (VGSCs) and the pharmacological blockade of Na, K-ATPase causing lysis of highly malignant cancer cells. . TOL offers an option for treating advanced carcinomas in companion animals. . Two cats and 2 dogs that presented to veterinary hospitals for evaluation and treatment of one of several forms of carcinoma. Methods: Digoxin was administered to achieve steady-state, therapeutic concentrations. The animals were then exposed to pulsed electric field stimulation. Pre- and posttreatment assessments of tumor size and quality of life were compared. The treatment frequency and survivability varied, based on the patient's premorbid functioning and response to treatment. Results: Regardless of cancer type, TOL consistently increased survival beyond expected, often improving, but without compromising of quality of life. . TOL warrants consideration as an option for managing advanced carcinomas.

Publication Source (Journal or Book title)

Case reports in veterinary medicine

First Page

2747108

Recommended Citation

Gould, H. J., Edenfield, S., Miller, P. R., Sherman, K. J., Melius, B., Whitney, A., Hunter, R. P., Del Piero, F., Tracey, D., & Paul, D. (2022). The Role of Targeted Osmotic Lysis in the Treatment of Advanced Carcinoma in Companion Animals: A Case Series. Case reports in veterinary medicine, 2022, 2747108. https://doi.org/10.1155/2022/2747108