Emerging concepts in hypertension

Authors

Joseph Francis, 1 Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University , Baton Rouge, Louisiana.
Robin L. Davisson

Document Type

Article

Publication Date

1-1-2014

Abstract

Cellular redox balance is vital in health and disease. In this Forum, we highlight the importance of reactive oxygen species (ROS) in the regulation of redox balance in different organ systems of the body and ROS contribution to the development of hypertension. The Forum examines interactions between oxidative and nitrosative stress in the brain, vasculature, and kidney, and redox effect on end-organ damage and hypertension. Furthermore, the Forum examines the role of immune cells in the modulation of hypertension. We also introduce a new role for endoplasmic reticulum stress in the induction of ROS and its possible contribution to the development of hypertension. Finally, we explore the clinical relevance of increased ROS in the setting of human hypertension.

Publication Source (Journal or Book title)

Antioxidants & redox signaling

First Page

69

Last Page

73

Recommended Citation

Francis, J., & Davisson, R. L. (2014). Emerging concepts in hypertension. Antioxidants & redox signaling, 20 (1), 69-73. https://doi.org/10.1089/ars.2013.5591