Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy

Authors

Sean Swetledge, Department of Biological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA, 70803, USA.
Jangwook P. Jung, Department of Biological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA, 70803, USA.
Renee Carter, Veterinary Clinical Sciences, Louisiana State University and LSU Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA, 70803, USA.
Cristina Sabliov, Department of Biological and Agricultural Engineering, Louisiana State University and LSU Agricultural Center, Baton Rouge, LA, 70803, USA. csabliov@agcenter.lsu.edu.

Document Type

Article

Publication Date

1-7-2021

Abstract

Advantages of polymeric nanoparticles as drug delivery systems include controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. Nanoparticle properties such as hydrophobicity, size, and charge, mucoadhesion, and surface ligands, as well as administration route and suspension media affect their ability to overcome ocular barriers and distribute in the eye, and must be carefully designed for specific target tissues and ocular diseases. This review seeks to discuss the available literature on the biodistribution of polymeric nanoparticles and discuss the effects of nanoparticle composition and administration method on their ocular penetration, distribution, elimination, toxicity, and efficacy, with potential impact on clinical applications.

Publication Source (Journal or Book title)

Journal of nanobiotechnology

First Page

10

Recommended Citation

Swetledge, S., Jung, J. P., Carter, R., & Sabliov, C. (2021). Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy. Journal of nanobiotechnology, 19 (1), 10. https://doi.org/10.1186/s12951-020-00745-9