Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice

Authors

Suidong Ouyang, Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Guangming Han, Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Xiaochu Wu, Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Zhengfan Jiang, The Education Ministry Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Ji-Ming Feng, Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address: jfeng@lsu.edu.

Document Type

Article

Publication Date

4-1-2016

Abstract

Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin's lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3(+)CD4(+) regulatory T cells (Tregs). In this study, we report that the ablation of golli protein, a negative regulator of CRAC (calcium release activated calcium) channel, in SJL mice results in an accelerated progression of Hodgkin's-like lymphoma which is accompanied by a facilitated conversion of FoxP3(+) Treg cells. Our results suggest that golli protein might affect the progression of Hodgkin's-like lymphomas through regulating the induction of Treg cells.

Publication Source (Journal or Book title)

Cellular immunology

First Page

41

Last Page

49

Recommended Citation

Ouyang, S., Han, G., Wu, X., Jiang, Z., & Feng, J. (2016). Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice. Cellular immunology, 302, 41-49. https://doi.org/10.1016/j.cellimm.2016.01.006