Vasopressin-induced Ca(2+) signals in human adipose-derived stem cells

Authors

Tran Doan Tran, Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address: trantran@iu.edu.
Jeffrey M. Gimble, LaCell LLC, New Orleans Bioinnovation Center, New Orleans, LA 70112, USA; Center for Stem Cell Research & Regenerative Medicine, Tulane University, New Orleans, LA 70112, USA. Electronic address: jgimble@tulane.edu.
Henrique Cheng, Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address: hcheng@lsu.edu.

Document Type

Article

Publication Date

3-1-2016

Abstract

Intracellular Ca(2+) signals are essential for stem cell differentiation due to their ability to control signaling pathways involved in this process. Arginine vasopression (AVP) is a neurohypophyseal hormone that increases intracellular Ca(2+) concentration during adipogenesis via V1a receptors, Gq-proteins and the PLC-IP3 pathway in human adipose-derived stromal/stem cells (hASCs). These Ca(2+) signals originate through calcium release from pools within the endoplasmic reticulum and the extracellular space. AVP supplementation to the adipogenic media inhibits adipogenesis and key adipocyte marker genes. This review focuses on the intersection between AVP, Ca(2+) signals and ASC differentiation.

Publication Source (Journal or Book title)

Cell calcium

First Page

135

Last Page

9

Recommended Citation

Tran, T. D., Gimble, J. M., & Cheng, H. (2016). Vasopressin-induced Ca(2+) signals in human adipose-derived stem cells. Cell calcium, 59 (2-3), 135-9. https://doi.org/10.1016/j.ceca.2015.12.006