Aryl hydrocarbon exposure induces expression of MMP-9 in human prostate cancer cell lines

Authors

Masudul Haque, Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Joseph Francis
Inder Sehgal

Document Type

Article

Publication Date

7-8-2005

Abstract

Although aromatic hydrocarbons have been extensively studied with regard to tumor formation, there has been little investigation into effects of these environmental chemicals on regulation of genes involved in tumor invasion. We investigated effects of three arylhydrocarbons on expression of MMP-9 in PC-3 and DU145 human prostate cancer cells. TCDD exposure lead to dose and time dependent increases in MMP-9 expression. Benzo(a)pyrene and a PAH-containing soot (BDS) also induced this MMP. These hydrocarbons also stimulated MMP-9 protein secretion. Our data demonstrate that aryl hydrocarbons can stimulate the production of MMP-9 in human prostate cancer cells.

Publication Source (Journal or Book title)

Cancer letters

First Page

159

Last Page

66

Recommended Citation

Haque, M., Francis, J., & Sehgal, I. (2005). Aryl hydrocarbon exposure induces expression of MMP-9 in human prostate cancer cell lines. Cancer letters, 225 (1), 159-66. https://doi.org/10.1016/j.canlet.2004.11.043