The role of neutrophils in equine laminitis

Document Type

Article

Publication Date

3-1-2018

Abstract

Equine laminitis is a devastating disease in which failure of the adhesion between the digital dermal and epidermal laminae at the basement membrane results in crippling lameness and structural damage to the foot of the horse. Laminitis occurring secondary to sepsis is known to result from a significant inflammatory response that includes leukocyte emigration into the lamellar tissue. These leukocytes, in particular the neutrophil, have been extensively evaluated in experimental models of sepsis-related laminitis in the horse. This review will discuss the relevant findings elucidated from these models and how these findings have affected the development of therapies used to treat this crippling disease.

Publication Source (Journal or Book title)

Cell and tissue research

First Page

541

Last Page

550

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