Laminitis Updates: Sepsis/Systemic Inflammatory Response Syndrome-Associated Laminitis

Authors

Britta Sigrid Leise, Department of Veterinary Clinical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, LA 70803, USA. Electronic address: bleise@lsu.edu.
Lee Ann Fugler, Department of Veterinary Clinical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, LA 70803, USA.

Document Type

Article

Publication Date

12-1-2021

Abstract

Sepsis or systemic inflammatory response syndrome (SIRS) -associated laminitis is a sequela to primary inflammatory conditions (eg, colitis, ischemic intestinal injury, pneumonia, metritis) and results from a dysregulated systemic inflammatory response that ultimately affects the digital lamellae. Local chemokine production, leukocyte migration, and proinflammatory mediator production occur within the lamellae that can lead to catastrophic lamellar failure. Controlling the primary disease, providing supportive care and anti-inflammatory therapy, applying digital cryotherapy, and providing mechanical support are cornerstones to the prevention of sepsis/SIRS-associated laminitis. Novel therapies targeting specific signaling pathways may provide additional therapeutic options in the future.

Publication Source (Journal or Book title)

The Veterinary clinics of North America. Equine practice

First Page

639

Last Page

656

Recommended Citation

Leise, B. S., & Fugler, L. A. (2021). Laminitis Updates: Sepsis/Systemic Inflammatory Response Syndrome-Associated Laminitis. The Veterinary clinics of North America. Equine practice, 37 (3), 639-656. https://doi.org/10.1016/j.cveq.2021.08.003