Differential mucin expression by respiratory syncytial virus and human metapneumovirus infection in human epithelial cells

Authors

Ma Del Baños-Lara, Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Boyang Piao, Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Antonieta Guerrero-Plata, Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA ; Center for Experimental Infectious Disease Research, Louisiana State University, Baton Rouge, LA 70803, USA.

Document Type

Article

Publication Date

1-1-2015

Abstract

Mucins (MUC) constitute an important component of the inflammatory and innate immune response. However, the expression of these molecules by respiratory viral infections is still largely unknown. Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two close-related paramyxoviruses that can cause severe low respiratory tract disease in infants and young children worldwide. Currently, there is not vaccine available for neither virus. In this work, we explored the differential expression of MUC by RSV and hMPV in human epithelial cells. Our data indicate that the MUC expression by RSV and hMPV differs significantly, as we observed a stronger induction of MUC8, MUC15, MUC20, MUC21, and MUC22 by RSV infection while the expression of MUC1, MUC2, and MUC5B was dominated by the infection with hMPV. These results may contribute to the different immune response induced by these two respiratory viruses.

Publication Source (Journal or Book title)

Mediators of inflammation

First Page

347292

Recommended Citation

Baños-Lara, M. D., Piao, B., & Guerrero-Plata, A. (2015). Differential mucin expression by respiratory syncytial virus and human metapneumovirus infection in human epithelial cells. Mediators of inflammation, 2015, 347292. https://doi.org/10.1155/2015/347292