HEPARINIZATION OF PET FILMS MODIFIED WITH ACRYLIC HYDROGELS.

Document Type

Conference Proceeding

Publication Date

12-1-1986

Abstract

Heparinization of PET films was achieved by reacting glutaraldehyde with heparin and poly(2-hydroxyethyl methacrylate) containing PET films. To this aim PET films previously treated with hot DLF were immersed in a mixture of monomer (HEMA) and initiator (AIBN). Semi-interpenetrated networks containing acrylic hydrogels were obtained by bulk polymerization of HEMA incorporated in the polyester matrix. The films were extracted with water and methanol, subjected to nitrogen glow discharge, soaked in an aqueous solution containing heparin and glutaraldehyde, dried and heated at 80 degree C. The unreacted heparin was removed by washing the films with 3M NaCl aqueous solution. The immobilization of heparin on the surface of acrylic hydrogel containing PET films was indirectly evidenced by chromatographying (g. c. ) the hydrolyzate obtained after the treatment of films with 4M CF//3 COOH.

Publication Source (Journal or Book title)

Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Material

First Page

894

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