Document Type
Patent
Patent Number
US 10870881B2
Abstract
The present invention relates to a device comprising a biomolecular processor. Each biomolecular processor has one or more bioreactor chambers defined by a solid substrate; a support structure within each bioreactor; a cleaving enzyme immobilized to the support structure and operatively positioned within the bioreactor chamber to cleave monomer or multimer units of a biopolymer molecule operatively engaged by the cleaving enzyme; and one or more time-of-flight channels formed in the solid substrate and fluidically coupled to said one or more bioreactor chambers. Each of the time-of-flight channels have two or more sensors including at least (i) a first sensor contacting the time-of-flight channel proximate to the input end of the channel and (ii) a second sensor contacting the time-of-flight channel proximate to the output end of channel. The present invention further relates to methods of sequencing and identifying biopolymer molecules using the device.
Application Number
US15/898,943
Assignees
Louisiana State University
Publication Date
12-22-2020
Recommended Citation
Soper, S., Barany, F., Grills, G., McCarley, R., Mckinney, C., Moldovan, D., Murphy, M., Nikitopoulos, D., Park, S., & Podlaha-Murphy, E. (2020). Biomolecular Processing Platform and Uses Thereof. Retrieved from https://repository.lsu.edu/science_patents/17