The (b)link between amotivation and psychosis: Insights through phasic eye blink rate

Authors

Jessica E. McGovern, Department of Psychology, Louisiana State University, United States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, United States; Desert Pacific Mental Illness Research, Education, and Clinical Center, VA Greater Los Angeles Healthcare System, United States. Electronic address: jessicamcgovern@ucla.edu.
Michael D. Masucci, Department of Psychology, Louisiana State University, United States; Center for Computation and Technology, Louisiana State University, United States.
Thanh P. Le, Department of Psychology, Louisiana State University, United States.
Alex S. Cohen, Department of Psychology, Louisiana State University, United States; Center for Computation and Technology, Louisiana State University, United States.

Document Type

Article

Publication Date

12-1-2020

Abstract

Motivation deficits within Schizophrenia Spectrum Disorders (SSDs) are associated with abnormal striatal dopamine responses during reward processing. Eye blink rate (EBR) has been used as a proxy for striatal dopamine; however, it is unclear whether EBR is sensitive to individual differences in amotivation. Amotivation (clinician-rated and self-reported) and EBR during an effort-based reward task were assessed in 28 outpatients with SSDs. EBR was lower during more "active" task phases relative to rest periods. Higher EBR during reward anticipation was associated with lower self-reported, but not clinician-rated, motivation. These preliminary results support a task-engagement, rather than striatal dopamine, account of EBR.

Publication Source (Journal or Book title)

Psychiatry research

First Page

113490

Recommended Citation

McGovern, J. E., Masucci, M. D., Le, T. P., & Cohen, A. S. (2020). The (b)link between amotivation and psychosis: Insights through phasic eye blink rate. Psychiatry research, 294, 113490. https://doi.org/10.1016/j.psychres.2020.113490