Regenerated cellulose micro-nano fiber matrices for transdermal drug release
Document Type
Article
Publication Date
5-1-2017
Abstract
In this work, biobased fibrous membranes with micro- and nano-fibers are fabricated for use as drug delivery carries because of their biocompatibility, eco-friendly approach, and potential for scale-up. The cellulose micro-/nano-fiber (CMF) matrices were prepared by electrospinning of pulp in an ionic liquid, 1-butyl-3-methylimidazolium chloride. A model drug, ibuprofen (IBU), was loaded on the CMF matrices by a simple immersing method. The amount of IBU loading was about 6% based on the weight of cellulose membrane. The IBU-loaded CMF matrices were characterized by Fourier-transform infrared spectroscopy, thermal gravimetric analysis, and scanning electron microscopy. The test of ibuprofen release was carried out in an acetate buffer solution of pH 5.5 and examined by UV–Vis spectroscopy. Release profiles from the CMF matrices indicated that the drug release rate could be determined by a Fickian diffusion mechanism.
Publication Source (Journal or Book title)
Materials Science and Engineering C
First Page
485
Last Page
492
Recommended Citation
Liu, Y., Nguyen, A., Allen, A., Zoldan, J., Huang, Y., & Chen, J. (2017). Regenerated cellulose micro-nano fiber matrices for transdermal drug release. Materials Science and Engineering C, 74, 485-492. https://doi.org/10.1016/j.msec.2016.12.048