Document Type
Article
Publication Date
10-18-2018
Abstract
Among adult lymphoma survivors, radiation treatment techniques that increase the excess radiation dose to organs at risk (OARs) put patients at risk for increased side effects, especially late toxicities. Minimizing radiation to OARs in adults patients with Hodgkin and non-Hodgkin lymphomas involving the mediastinum is the deciding factor for the choice of treatment modality. Proton therapy may help to reduce the radiation dose to the OARs and reduce toxicities, especially the risks for cardiac morbidity and second cancers. Becauseproton therapymay have some disadvantages, identifying the patients and the circumstances that may benefit the most from proton therapy is important. We present modern guidelines to identify adult lymphoma patients who may derive the greatest benefit from proton therapy, along with an analysis of the advantages and disadvantages of proton treatment. (Blood. 2018;132(16):1635-1646).
Publication Source (Journal or Book title)
Blood
First Page
1635
Last Page
1646
Recommended Citation
Dabaja, B., Hoppe, B., Plastaras, J., Newhauser, W., Rosolova, K., Flampouri, S., Mohan, R., Mikhaeel, N., Kirova, Y., Specht, L., & Yahalom, J. (2018). Proton therapy for adults with mediastinal lymphomas: The international lymphoma radiation oncology group guidelines. Blood, 132 (16), 1635-1646. https://doi.org/10.1182/blood-2018-03-837633