Document Type
Article
Publication Date
12-1-2024
Abstract
Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a “2-hit” model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF. These results underscore the importance of skeletal muscle metabolism to improve exercise intolerance in HFpEF.
Recommended Citation
Quiriarte, H., Noland, R., Stampley, J., Davis, G., Li, Z., Cho, E., Kim, Y., Doiron, J., Spielmann, G., Ghosh, S., Shah, S., Irving, B., Lefer, D., & Allerton, T. (2024). Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF. Retrieved from https://repository.lsu.edu/pbrc_basic_science_pubs/80
