Identifier

etd-07132005-141738

Degree

Doctor of Philosophy (PhD)

Department

Chemistry

Document Type

Dissertation

Abstract

Nature has provided a vast number of compounds that have medicinal application. The use of these compounds provided by nature however, is limited by the amount of a specific compound that nature provides. The synthesis of these molecules and their derivatives provides an even greater number of compounds for biological screening. Various pyrroles, the heterocyclic building blocks of porphyrins, can be prepared synthetically over several steps. The implementation of carboranes on pyrrole rings intrinsically provides substrates that can be converted into porphyrins bearing carborane substituents. The condensation of these carboranylpyrroles with carboranylaldehydes provides carboranylporphyrins bearing a higher order of carborane substitution. The conversion of these carboranylporphyrins into their water-soluble nido derivatives provides several compounds whose biological properties are currently being explored. The use of peptides in the treatment of neurodegenerative diseases such as Alzheimer's provides a need for novel peptides. Peptides typically are synthesized through extensive use of solid-phase chemistry, protecting group chemistry, and linkers. The manipulation of the reactivity of these groups provides more advanced methods for producing novel peptides. The development of novel protecting groups and linkers on solid-phase resins have been attempted and have shown preliminary success. The preliminary results of the biological studies of two of the molecules from this dissertation have shown positive activity for potential use in cancer therapy. These results as well as future findings will soon be published.

Date

2005

Document Availability at the Time of Submission

Release the entire work immediately for access worldwide.

Committee Chair

M. Graca H. Vicente

DOI

10.31390/gradschool_dissertations.2775

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