Synthesis of aza-BODIPY Fluorophores for Conjugation with EGFR-Targeting Molecules
Presentation Type
Poster
Conference Date
Spring 4-17-2026
Abstract
Near-infrared (NIR) absorbing and emitting aza-BODIPY fluorophores bearing two isothiocyanate functional groups will be synthesized via a five-step route to enable site-selective conjugation to the N-terminus of peptides and small molecules, including tyrosine kinase inhibitors. Structural and photophysical properties will be systematically characterized using spectroscopic and analytical methods. The fluorophores will be conjugated to epidermal growth factor receptor (EGFR)–targeting peptides and related ligands, followed by purification and detailed chemical characterization. To enhance aqueous solubility, selected derivatives will also be conjugated to glucose. Targeting efficiency and biological performance will be evaluated through in vitro cellular assays and in vivo animal models to assess EGFR-specific localization and imaging potential..
Presenter
Jada Yeboah
Recommended Citation
Yeboah, J. (2026). Synthesis of aza-BODIPY Fluorophores for Conjugation with EGFR-Targeting Molecules. Retrieved from https://repository.lsu.edu/discover_pubs/12
Faculty Mentor
Graca Vicente
Award
3rd Place, LSU College of Science
Academic Major
Biochemistry