The China Brain Multi-omics Atlas Project (CBMAP)

Authors

• Dan Zhou, Zhejiang University School of Public Health
• Yuan Zhou, Zhejiang University School of Public Health
• Zeyu Sun, The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
• Feiyang Ji, Zhejiang University School of Medicine
• Dandan Zhang, Department of Pathology and Pathophysiology

Document Type

Article

Publication Date

1-1-2026

Abstract

The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1000 human brains (Phase I), spanning a broad age range and multiple regions in China, to address the underrepresentation of East Asian populations in brain research. By integrating genome, epigenome, transcriptome, proteome (including multiple post-translational modifications), and metabolome data, CBMAP is set to provide a rich and invaluable resource for investigating the molecular underpinnings of aging-related brain phenotypes and neuropsychiatric disorders. Leveraging high-throughput omics data and advanced technologies, such as spatial transcriptomics, proteomics, and single-nucleus 3D chromatin structure analysis, this atlas will serve as a crucial resource for the brain science community, illuminating disease mechanisms and enhancing the utility of data from genome-wide association studies (GWAS). CBMAP is also poised to accelerate drug discovery and precision medicine for brain disorders.

Publication Source (Journal or Book title)

Molecular Psychiatry

First Page

591

Last Page

598

Recommended Citation

Zhou, D., Zhou, Y., Sun, Z., Ji, F., & Zhang, D. (2026). The China Brain Multi-omics Atlas Project (CBMAP). Molecular Psychiatry, 31 (1), 591-598. https://doi.org/10.1038/s41380-025-03250-3