Enantioselective Functionalization of Enamides at the β-Carbon Center with Indoles
Abstract
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim We report an enantioconvergent approach for the functionalization of enamides at the β-carbon atom, which involves a chiral Brønsted acid induced tautomerization of 2-amidoallyl into 1-amidoallyl cations. These putative reactive intermediates were produced by ionization of racemic α-hydroxy enamides with a chiral Brønsted acid and captured with substituted indoles in a highly regio- and enantioselective manner.
This paper has been withdrawn.