Synthesis and cellular properties of a 1 3 1 substituted chlorin e 6-nevirapine conjugate

Document Type

Article

Publication Date

7-1-2021

Abstract

The synthesis of a chlorin e6-nevirapine conjugate is reported, in which the nevirapine moiety is attached to the 131-position of chlorin e6 via a diethylene glycol linker. This conjugate was found to be nontoxic in the dark (IC50 > 200 μM), but highly phototoxic (IC50 = 0.21 μM at 1.5 J/cm2) toward human HEp2 cells. The chlorin e6-nevirapine conjugate accumulated within cells in multiple organelles, including the Golgi, lysosomes and mitochondria. On the other hand, nevirapine was found to be nontoxic to HEp2 cells.

Publication Source (Journal or Book title)

Journal of Porphyrins and Phthalocyanines

First Page

696

Last Page

702

This document is currently not available here.

Share

COinS