Applications of Laser Desorption Ionization and Laser Desorption/Ablation with Postionization

Document Type

Article

Publication Date

1-1-2020

Abstract

Laser desorption (LD) and laser ablation (LA) have been applied to the mass spectrometry (MS) analysis of a wide variety of sample types and can be classified based on whether they provide atomic or molecular information. This chapter discusses advantages and disadvantages of the various LD/LA-MS methods. Laser desorption ionization mass spectrometry (LDI-MS)-based elemental analysis of solids can be performed with standard nanosecond pulsed lasers without any need for inductively coupled plasma. The most popular laser-based MS method for molecular analysis is matrix-assisted laser desorption ionization (MALDI) using nanosecond ultraviolet (ns-UV) pulsed lasers. Atmospheric pressure matrix-assisted laser desorption ionization (AP-MALDI) is a variant of MALDI, where samples are analyzed at ambient pressure. One advantage of AP-MALDI is that the samples do not need to be dried before analysis. The chapter also provides a discussion on laser ablation sampling for solid or liquid collection.

Publication Source (Journal or Book title)

Photoionization and Photo Induced Processes in Mass Spectrometry Fundamentals and Applications

First Page

327

Last Page

357

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