A Visible-Light-Driven O-Glycosylation with Selenoglycosides Mediated by Chalcogen Bonding to Umemoto's Reagent
Document Type
Article
Publication Date
7-21-2025
Abstract
The activation of chalcogenoglycosides for O-glycosylation typically involves strong electrophiles requiring low temperature. Herein, we demonstrate that visible-light irradiation of selenoglycosides in the presence of Umemoto's reagent results in often high-yielding O-glycosylation. We provide evidence that this process is mediated by a novel mode of reactivity, specifically photoinduced electron transfer within a chalcogen-bonded complex.
Publication Source (Journal or Book title)
Angewandte Chemie International Edition
Recommended Citation
Valenzuela, E., Duong, T., Pradeep, V., He, X., Dobson, J., Lee, S., Lopata, K., & Ragains, J. (2025). A Visible-Light-Driven O-Glycosylation with Selenoglycosides Mediated by Chalcogen Bonding to Umemoto's Reagent. Angewandte Chemie International Edition, 64 (30) https://doi.org/10.1002/anie.202508424