Title
The structure of human 5-lipoxygenase
Document Type
Article
Publication Date
1-14-2011
Abstract
The synthesis of both proinflammatory leukotrienes and anti-inflammatory lipoxins requires the enzyme 5-lipoxygenase (5-LOX). 5-LOX activity is short-lived, apparently in part because of an intrinsic instability of the enzyme. We identified a 5-LOX-specific destabilizing sequence that is involved in orienting the carboxyl terminus, which binds the catalytic iron. Here, we report the crystal structure at 2.4 angstrom resolution of human 5-LOX stabilized by replacement of this sequence.
Publication Source (Journal or Book title)
Science (New York, N.Y.)
First Page
217
Last Page
9
Recommended Citation
Gilbert, N. C., Bartlett, S. G., Waight, M. T., Neau, D. B., Boeglin, W. E., Brash, A. R., & Newcomer, M. E. (2011). The structure of human 5-lipoxygenase. Science (New York, N.Y.), 331 (6014), 217-9. https://doi.org/10.1126/science.1197203