Title
Synthesis, characterization and biological evaluation of dipicolylamine sulfonamide derivatized platinum complexes as potential anticancer agents
Document Type
Article
Publication Date
5-13-2021
Abstract
Three new Pt complexes, [PtCl(N(SO(2-nap))dpa)], [PtCl(N(SO(1-nap))dpa)] and [PtCl(N(SOpip)dpa)], containing a rare 8-membered ring were synthesized in good yield and high purity by utilizing the ligands N(SO(2-nap))dpa, N(SO(1-nap))dpa and N(SOpip)dpa, which contain a dipicolylamine moiety. Structural studies of all three complexes confirmed that the ligands are bound in a bidentate mode Pt-N bonds forming a rare 8-membered ring. The intense fluorescence displayed by the ligands is quenched upon coordination to Pt. According to time dependent density functional theory (TDDFT) calculations, the key excitations of N(SO(2-nap))dpa and [PtCl(N(SO(1-nap))dpa)] involve the 2-nap-ligand-centered π → π* excitations. While all six compounds have shown antiproliferative activity against human breast cancer cells (MCF-7), the N(SOpip)dpa and N(SO(2-nap))dpa ligands and [PtCl((NSOpip)dpa)] complex have shown significantly high cytotoxicity, directing them to be further investigated as potential anti-cancer drug leads.
Publication Source (Journal or Book title)
RSC advances
First Page
17658
Last Page
17668
Recommended Citation
Thushara, N., Darshani, T., Samarakoon, S. R., Perera, I. C., Fronczek, F. R., Sameera, W. M., & Perera, T. (2021). Synthesis, characterization and biological evaluation of dipicolylamine sulfonamide derivatized platinum complexes as potential anticancer agents. RSC advances, 11 (29), 17658-17668. https://doi.org/10.1039/d1ra00842k
