Preparation and Phytotoxicity Evaluation of 11,13-Dehydro -Guaianolides
Authors
Nuria Chinchilla, Allelopathy Group, Department of Organic Chemistry, School of Sciences, Institute of Biomolecules (INBIO) , University of Cadiz , C/República Saharaui, s/n , 11510 Puerto Real ( Cádiz ), Spain.
Alejandro Santana, Allelopathy Group, Department of Organic Chemistry, School of Sciences, Institute of Biomolecules (INBIO) , University of Cadiz , C/República Saharaui, s/n , 11510 Puerto Real ( Cádiz ), Spain.
Rosa M. Varela, Allelopathy Group, Department of Organic Chemistry, School of Sciences, Institute of Biomolecules (INBIO) , University of Cadiz , C/República Saharaui, s/n , 11510 Puerto Real ( Cádiz ), Spain.
Frank R. Fronczek, Department of Chemistry , Louisiana State University , Baton Rouge , Louisiana 70803 , United States.
José M. Molinillo, Allelopathy Group, Department of Organic Chemistry, School of Sciences, Institute of Biomolecules (INBIO) , University of Cadiz , C/República Saharaui, s/n , 11510 Puerto Real ( Cádiz ), Spain.
Francisco A. Macías, Allelopathy Group, Department of Organic Chemistry, School of Sciences, Institute of Biomolecules (INBIO) , University of Cadiz , C/República Saharaui, s/n , 11510 Puerto Real ( Cádiz ), Spain.
Publication Date
9-27-2019
Abstract
11,13-Dehydro -guaianolides, a particular type of sesquiterpene lactones, were synthesized from the commercially available α-santonin () using a facile strategy involving a high-yielding photochemical reaction. Natural products and from were synthesized in good yields. Specifically, compound was obtained in five steps with an overall yield of 17%. The sesquiterpene lactones were tested in the etiolated wheat coleoptile bioassay, and the most active compounds were assayed on standard target species. Guaianolide showed the highest phytotoxic activities when compared with the known herbicide Logran.
Publication Source (Journal or Book title)
Journal of natural products
Recommended Citation
Chinchilla, N., Santana, A., Varela, R. M., Fronczek, F. R., Molinillo, J. M., & Macías, F. A.
(2019). Preparation and Phytotoxicity Evaluation of 11,13-Dehydro -Guaianolides. Journal of natural products, 82 (9), 2501-2508.
https://doi.org/10.1021/acs.jnatprod.9b00285
