"Mitigation of late cardiovascular effects of oxygen ion radiation by γ" by Ashley S. Nemec-Bakk, Vijayalakshmi Sridharan et al.

Faculty Publications

Title

Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model

Authors

Ashley S. Nemec-Bakk, Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: anemecbakk@uams.edu.
Vijayalakshmi Sridharan, Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Reid D. Landes, Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Preeti Singh, Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Maohua Cao, College of Dentistry, Texas A&M University, Dallas TX, USA.
John W. Seawright, McLennan Community College, Waco, TX, USA.
Xingui Liu, Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.
Guangrong Zheng, Department of Medicinal Chemistry, University of Florida, Gainesville, FL, USA.
Paari Dominic, Department of Medicine and Center of Excellence for Cardiovascular Diseases & Sciences, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Rupak Pathak, Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Marjan Boerma, Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Document Type

Article

Publication Date

11-1-2021

Abstract

PURPOSE: While there is concern about degenerative tissue effects of exposure to space radiation during deep-space missions, there are no pharmacological countermeasures against these adverse effects. γ-Tocotrienol (GT3) is a natural form of vitamin E that has anti-oxidant properties, modifies cholesterol metabolism, and has anti-inflammatory and endothelial cell protective properties. The purpose of this study was to test whether GT3 could mitigate cardiovascular effects of oxygen ion (O) irradiation in a mouse model. MATERIALS AND METHODS: Male C57BL/6 J mice were exposed to whole-body O (600 MeV/n) irradiation (0.26-0.33 Gy/min) at doses of 0 or 0.25 Gy at 6 months of age and were followed up to 9 months after irradiation. Animals were administered GT3 (50 mg/kg/day s.c.) or vehicle, on Monday - Friday starting on day 3 after irradiation for a total of 16 administrations. Ultrasonography was used to measure in vivo cardiac function and blood flow parameters. Cardiac tissue remodeling and inflammatory infiltration were assessed with histology and immunoblot analysis at 2 weeks, 3 and 9 months after radiation. RESULTS: GT3 mitigated the effects of O radiation on cardiac function, the expression of a collagen type III peptide, and markers of mast cells, T-cells and monocytes/macrophages in the left ventricle. CONCLUSIONS: GT3 may be a potential countermeasure against late degenerative tissue effects of high-linear energy transfer radiation in the heart.

Publication Source (Journal or Book title)

Life sciences in space research

First Page

Last Page

Recommended Citation

Nemec-Bakk, A. S., Sridharan, V., Landes, R. D., Singh, P., Cao, M., Seawright, J. W., Liu, X., Zheng, G., Dominic, P., Pathak, R., & Boerma, M. (2021). Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model. Life sciences in space research, 31, 43-50. https://doi.org/10.1016/j.lssr.2021.07.006

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