"Furanocoumarin with Phytotoxic Activity from the Leaves of (Rutaceae)" by Kumudini M. Meepagala, Amy K. Bracken et al.

Faculty Publications

Title

Furanocoumarin with Phytotoxic Activity from the Leaves of (Rutaceae)

Authors

Kumudini M. Meepagala, United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P.O. Box 1848, University, Mississippi 38677, United States.
Amy K. Bracken, United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P.O. Box 1848, University, Mississippi 38677, United States.
Frank R. Fronczek, Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Robert D. Johnson, United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P.O. Box 1848, University, Mississippi 38677, United States.
David E. Wedge, United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P.O. Box 1848, University, Mississippi 38677, United States.
Stephen O. Duke, United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P.O. Box 1848, University, Mississippi 38677, United States.

Document Type

Article

Publication Date

1-12-2021

Abstract

Bioassay-guided fractionation of the ethyl acetate extract of leaves was carried out to identify phytotoxic and antifungal constituents. A novel phytotoxic furanocoumarin 8-(3-methylbut-2-enyloxy)-marmesin acetate () and its deacyl analog 8-(3-methylbut-2-enyloxy)-marmesin () were isolated. The X-ray crystal structure determination is reported for the first time for . Both and have the S configuration at C-2' based on X-ray crystallographic data. Both these compounds inhibited the growth of the dicot (lettuce) and the monocot with a more pronounced inhibitory effect on the monocots at 330 μM by . In Hegelm phytotoxicity bioassay, the IC value for was 26 μM, whereas had an IC value of 102 μM. Compounds and were weakly antifungal against Brooks in TLC bioautography.

Publication Source (Journal or Book title)

ACS omega

First Page

401

Last Page

407

Recommended Citation

Meepagala, K. M., Bracken, A. K., Fronczek, F. R., Johnson, R. D., Wedge, D. E., & Duke, S. O. (2021). Furanocoumarin with Phytotoxic Activity from the Leaves of (Rutaceae). ACS omega, 6 (1), 401-407. https://doi.org/10.1021/acsomega.0c04778

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