"Fe-Catalyzed Direct α C-H Amination of Carbonyl Compounds" by Siva Murru, Charles Seth Lott et al.

Faculty Publications

Title

Fe-Catalyzed Direct α C-H Amination of Carbonyl Compounds

Authors

Siva Murru, †Department of Chemistry, University of Louisiana at Lafayette, Lafayette, Louisiana 70504, United States.
Charles Seth Lott, †Department of Chemistry, University of Louisiana at Lafayette, Lafayette, Louisiana 70504, United States.
Frank R. Fronczek, ‡Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Radhey S. Srivastava, †Department of Chemistry, University of Louisiana at Lafayette, Lafayette, Louisiana 70504, United States.

Document Type

Article

Publication Date

5-1-2015

Abstract

A direct Fe-catalyzed α-amination of 1,3-dicarbonyl compounds has been accomplished using arylhydroxylamines as aminating agents. This novel protocol allows convenient access to α-amino carbonyl derivatives without the need for any postreaction manipulations. This is an operationally simple procedure that works at low temperatures in shorter reaction times and produces high yields with excellent N-selectivity.

Publication Source (Journal or Book title)

Organic letters

First Page

2122

Last Page

Recommended Citation

Murru, S., Lott, C. S., Fronczek, F. R., & Srivastava, R. S. (2015). Fe-Catalyzed Direct α C-H Amination of Carbonyl Compounds. Organic letters, 17 (9), 2122-5. https://doi.org/10.1021/acs.orglett.5b00710

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