Title

Chloride to the rescue

Document Type

Article

Publication Date

7-26-2019

Abstract

On the fiftieth anniversary of the discovery of the Ser-His-Asp catalytic triad, perhaps the most unusual variation on the textbook classic is described: An incomplete catalytic triad in a hydrolase is rescued by a chloride ion (Fig. 1). Structural and functional data provide compelling evidence that the active site of a phospholipase from employs the anion in place of the commonly observed Asp, reminding us that even well-trodden scientific ground has surprises in store.

Publication Source (Journal or Book title)

The Journal of biological chemistry

First Page

11402

Last Page

11403

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