"Cardiorespiratory profiling reveals primary breathing dysfunction in K" by Hemangini Dhaibar, Nicole M. Gautier et al.

Faculty Publications

Title

Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy

Authors

Hemangini Dhaibar, Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center Shreveport, LA 71103, USA. Electronic address: hdhaib@lsuhsc.edu.
Nicole M. Gautier, Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center Shreveport, LA 71103, USA. Electronic address: ngauti@lsuhsc.edu.
Oleg Y. Chernyshev, Department of Neurology, Division of Sleep Medicine, Louisiana State University Health Sciences Center Shreveport, LA 71103, USA. Electronic address: ochern@lsuhsc.edu.
Paari Dominic, Department of Internal Medicine, Section of Cardiology, Louisiana State University Health Sciences Center Shreveport, LA 71103, USA. Electronic address: pdomi2@lsuhsc.edu.
Edward Glasscock, Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center Shreveport, LA 71103, USA. Electronic address: aglas1@lsuhsc.edu.

Document Type

Article

Publication Date

7-1-2019

Abstract

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but the relative importance of underlying cardiac and respiratory mechanisms remains unclear. To illuminate the interactions between seizures, respiration, cardiac function, and sleep that contribute to SUDEP risk, here we developed a mouse epilepsy monitoring unit (EMU) to simultaneously record video, electroencephalography (EEG), electromyography (EMG), plethysmography, and electrocardiography (ECG) in a commonly used genetic model of SUDEP, the Kcna1 knockout (Kcna1) mouse. During interictal periods, Kcna1 mice exhibited an abnormal absence of post-sigh apneas and a 3-fold increase in respiratory variability. During spontaneous convulsive seizures, Kcna1 mice displayed an array of aberrant breathing patterns that always preceded cardiac abnormalities. These findings support respiratory dysfunction as a primary risk factor for susceptibility to deleterious cardiorespiratory sequelae in epilepsy and reveal a new role for Kcna1-encoded Kv1.1 channels in the regulation of basal respiratory physiology.

Publication Source (Journal or Book title)

Neurobiology of disease

First Page

502

Last Page

511

Recommended Citation

Dhaibar, H., Gautier, N. M., Chernyshev, O. Y., Dominic, P., & Glasscock, E. (2019). Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy. Neurobiology of disease, 127, 502-511. https://doi.org/10.1016/j.nbd.2019.04.006

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