Title
Antileukemic α-pyrone derivatives from the endophytic fungus
Authors
Ahmed M. Metwaly, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo, Egypt.
Frank R. Fronczek, Department of Chemistry, College of Science, Louisiana State University, Baton Rouge, LA 70803, USA.
Guoyi Ma, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Hazem A. Kadry, Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo, Egypt.
Atef A. El-Hela, Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo, Egypt.
Abd-Elsalam I. Mohammad, Department of Pharmacognosy, Faculty of Pharmacy, University of Al-Azhar, Cairo, Egypt.
Stephen J. Cutler, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Samir A. Ross, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Publication Date
6-11-2014
Abstract
Four new (-) and two known ( and ) α-pyrone derivatives have been isolated from , an endophytic fungus from , leaves. The isolated compounds were chemically identified to be 5-butyl-4-methoxy-6-methyl-2-pyran-2-one (), 5-butyl-6-(hydroxymethyl)-4-methoxy-2-pyran-2-one (), 5-(1-hydroxybutyl)-4-methoxy-6-methyl-2-pyran-2-one (), 4-methoxy-6-methyl-5-(3-oxobutyl)-2-pyran-2-one (), 5-(2-hydroxyethyl)-4-methoxy-6-methyl-2-pyran-2-one (), and 5-[(2)-but-2-en-1-yl]-4-methoxy-6-methyl-2-pyran-2-one (). Compounds and showed moderate antileukemic activities against HL60 cells with IC values of 2.2 and 0.9 μM and against K562 cells with IC values of 4.5 and 1.5 μM, respectively.
Publication Source (Journal or Book title)
Tetrahedron letters
Recommended Citation
Metwaly, A. M., Fronczek, F. R., Ma, G., Kadry, H. A., El-Hela, A. A., Mohammad, A. I., Cutler, S. J., & Ross, S. A.
(2014). Antileukemic α-pyrone derivatives from the endophytic fungus. Tetrahedron letters, 55 (24), 3478-3481.
https://doi.org/10.1016/j.tetlet.2014.04.085
