Title
A dual input DNA-based molecular switch
Document Type
Article
Publication Date
11-1-2014
Abstract
We have designed and characterized a DNA-based molecular switch which processes two physiologically relevant inputs: pH (i.e. alkalinisation) and enzymatic activity, and generates a chemical output (in situ synthesized oligonucleotide). The design, based on allosteric interactions between i-motif and hairpin stem within the DNA molecule, addresses such critical physiological system parameters as molecular simplicity, tunability, orthogonality of the two input sensing domains, and compatibility with intracellular operation/delivery.
Publication Source (Journal or Book title)
Molecular bioSystems
First Page
2810
Last Page
4
Recommended Citation
Nesterova, I. V., Elsiddieg, S. O., & Nesterov, E. E. (2014). A dual input DNA-based molecular switch. Molecular bioSystems, 10 (11), 2810-4. https://doi.org/10.1039/c4mb00363b