Title
Fluorescence characterization of the cyclodextrin/pyrene complex interaction with chiral alcohols and diols
Document Type
Article
Publication Date
1-1-1994
Abstract
The chiral properties of cyclodextrins (CDs) facilitate the formation of diastereomeric complexes with a number of pesticides and pharmaceuticals which are also frequently composed of one or more chiral centers. The roles of chirality and structural volume in CD binding to a homologous series of linear, chiral alcohols and diols are evaluated by comparing the trend in the pyrene fluorescence I/III band ratio and the hydrophobicity for the CD/pyrene complex with CD/pyrene complexes incorporating achiral alcohols. Stronger hydrophobicity is observed for complexes capped by chiral alcohols relative to complexes formed with a similar achiral counterpart, suggesting the importance of the alcohol chiral center. Furthermore, the diols induce a more hydrophobic environment than their alcohol counterparts with the β-CD/pyrene complex, while the converse is the case for the γ-CD systems. The systems involving γ-CD were also compared by use of pyrene fluorescence lifetime measurements.
Publication Source (Journal or Book title)
Applied Spectroscopy
First Page
581
Last Page
586
Recommended Citation
Schuette, J., Will, A., Agbaria, R., & Warner, I. (1994). Fluorescence characterization of the cyclodextrin/pyrene complex interaction with chiral alcohols and diols. Applied Spectroscopy, 48 (5), 581-586. https://doi.org/10.1366/0003702944924934