Syntheses of some new porphyrin photosensitizers for photodynamic therapy

Fuu Yau Shiau, University of California, Davis
Paul A. Liddell, University of California, Davis
M. Graca H. Vicente, University of California, Davis
N. Venkata Ramana, University of California, Davis
Kishore Ramachandran, University of California, Davis
Shwn Ji H. Lee, University of California, Davis
Ravindra K. Pandey, Oncologic Foundation of Buffalo
Thomas J. Dougherty, Roswell Park Cancer Institute
Kevin M. Smith, University of California, Davis

Abstract

© 1990 SPIE. Syntheses and chemical characterization of a number of new porphyrin-derived sensitizers, related to Photofrin-II and otherwise, are described. The major thrust of our more recent work centers on preparation of porphyrin oligomers linked by ester, ether, or carbon-carbon bonds, as well as photosensitizers with long-wavelength absorbance. Where appropriate, PDT activity is briefly mentioned.