Title

Stability of tin etiopurpurin

Document Type

Article

Publication Date

1-1-2005

Abstract

Formulations of the tin etiopurpurin (SnET2) have been observed to undergo a spectral change on storage in dimethylformamide solution. This results in an alteration in the action spectrum, with enhanced photodynamic activity at lower wavelengths and decreased activity at 660 nm. On the basis of structural considerations, a reduced analog of SnET2 was prepared with an absorbance maximum at 640 nm. Formation of this product, termed SnET2H2 relieves steric strain inherent in the parent molecule. Nuclear magnetic resonance, spectral and photodynamic data are consistent with the formation of SnET2H 2 during SnET2 storage. Slight modifications in the original synthesis are also reported, resulting in improved yields of intermediate products. © 2005 American Society for Photobiology.

Publication Source (Journal or Book title)

Photochemistry and Photobiology

First Page

149

Last Page

153

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