Title
Synthesis, cellular uptake and animal toxicity of a tetra(carboranylphenyl) -tetrabenzoporphyrin
Document Type
Article
Publication Date
3-15-2006
Abstract
A water-soluble nido-carboranyl-tetrabenzoporphyrin has been synthesized in 43% overall yield, by condensation of butanopyrrole with a carboranylbenzaldehyde, followed by metal insertion, oxidation, demetallation and deboronation reactions. This compound accumulated within human glioblastoma T98G cells to a significant higher extent than a structurally related nido-carboranylporphyrin, and localized preferentially in the cell lysosomes. Animal toxicity studies using male and female BALB/c mice revealed that both compounds are non-toxic even at a dose of 160 mg/kg, administered intraperitoneally as a single injection at a concentration of 4 mg/mL. It is concluded that the tetra(carboranylphenyl)-tetrabenzoporphyrin is a promising new sensitizer for the treatment of malignant tumors. © 2005 Elsevier Ltd. All rights reserved.
Publication Source (Journal or Book title)
Bioorganic and Medicinal Chemistry
First Page
1871
Last Page
1879
Recommended Citation
Gottumukkala, V., Ongayi, O., Baker, D., Lomax, L., & Vicente, M. (2006). Synthesis, cellular uptake and animal toxicity of a tetra(carboranylphenyl) -tetrabenzoporphyrin. Bioorganic and Medicinal Chemistry, 14 (6), 1871-1879. https://doi.org/10.1016/j.bmc.2005.10.037