Title
Synthesis and toxicity of cobaltabisdicarbollide-containing porphyrins of high boron content
Document Type
Article
Publication Date
1-1-2011
Abstract
Two porphyrins of high boron content (OCP and HCPPEG) were prepared in high yields from the reaction of the corresponding tri- and tetra-(dihydroxyphenyl) porphyrins with zwitterionic cobaltabisdicarbollide [3,3′-Co(8-C 4H8O2-1,2-C2B9H 10)(1′,2′-C2B9H11)]. Both porphyrins were found to have low cytotoxicity toward human HEp2 cells, and to localize subcellularly mainly in the cell lysosomes. Animal toxicity investigations using male and female BALB/c mice also revealed low toxicity for both compounds. The determined maximum tolerated dose (MTD) for these boronated porphyrins administered intraperitoneally were 160 mg/kg for OCP and 320 mg/kg for HCPPEG. Our studies warrant further development of these porphyrins of high boron content, and in particular of HCPPEG, as boron delivery vehicles for BNCT. © 2011 World Scientific Publishing Company.
Publication Source (Journal or Book title)
Journal of Porphyrins and Phthalocyanines
First Page
973
Last Page
983
Recommended Citation
Bhupathiraju, N., Gottumukkala, V., Hao, E., Hu, X., Fronczek, F., Baker, D., Wakamatsu, N., & Vicente, M. (2011). Synthesis and toxicity of cobaltabisdicarbollide-containing porphyrins of high boron content. Journal of Porphyrins and Phthalocyanines, 15 (9-10), 973-983. https://doi.org/10.1142/S1088424611003902