New water-soluble phthalocyanines and other tetrapyrroles for application in photodynamic therapy

Wei Liu, Louisiana State University
M. Ravi Kumar, Louisiana State University
M. Graça H. Vicente, Louisiana State University
Frank R. Fronczek, Louisiana State University
Kevin M. Smith, Louisiana State University

Abstract

The syntheses and properties of novel water-soluble phthalocyanies are reported, as well as new chemistry of tetrabutanoporphyrins aimed at the preparation of new, functionalizable, tribenzoporphyrin systems. The objective of the study is to provide new second-generation photosensitizing drugs, with long-wavelength absorption, for use in the photodynamic therapy of tumors.